Metabolic Control of Cell Growth-Rate
Fast growing bacteria, like Bacillus subtilis or Escherichia coli, duplicate in only about 20 minutes and they efficiently and robustly alter their growth rate in response to environmental fluctuations. My main interest is to understand how flux through metabolic pathways, such as cell wall biosynthesis, DNA replication or translation, are coupled with the cell growth-rate control.
Control of Cell Growth-Rate through Physical-Forces
In the last few years it has been discovered how physical factors, such as turgor pressure or membrane potential, are critical for the regulation of cell growth. My goal is to understand how these factors integrate with the molecular pathway that also dictate growth rate.
To address these questions, I am looking at growth at the single-cell and population level, combining molecular biology methods with computational analysis and mathematical modeling.